Trypanocidal effects of Balanites aegyptiaca Del. (Zygophyllaceae) Leaf ‎Extract and Suramin on Trypanosoma evansi Experimental Infection in ‎Albino rat

TTrypanosoma evansi, is one among several species of Trypanosomes responsible for a major protozoan parasitic disease domestic animals. The current study aimed to investigate the trypanocidal effects aqueous and methanolic leaf extracts Balanites aegyptiacaDel (Zygophyllaceae) suramin on albino rats infected with Trypanosoma evansi. In total, 35 Swiss randomly separated into seven (7) groups (A- G) 5 each were intraperitoneally 0.5 ml blood containing 1.0 × 106trypanosomes treated 7 days single dose respectively by day 12 post infection (p.i). Clinical parameters haematological indices evaluated. Preliminary phytochemical screening revealed that Balanitesaegyptiaca contained following metabolites: flavonoids, tannin, saponins, alkaloids, glycosides, steroids volatile oils. There was marked initial reduction in Packed Cell Volume (PCV), Haemoglobin (Hb) Red Blood Cells (RBCs) counts infected/untreated group (Group A) but treatment B. aegyptiaca extracts, these values reversed. Furthermore, there reversion leukopenia after individually (150 mg/kg aegyptiaca; Group B) from 3.47±1.49 103/mm3 p.i. 9.03±2.18 40 p.i., similar pre-infection value. conclusion, caused clinical changes ameliorated extract